1,4-Dithiothreitol
Title: 1,4-Dithiothreitol
CAS Registry Number: 3483-12-3
CAS Name: (2R,3R)-rel-1,4-Dimercapto-2,3-butanediol
Additional Names: Cleland's reagent; threo-2,3-dihydroxy-1,4-dithiolbutane
Molecular Formula: C4H10O2S2
Molecular Weight: 154.25
Percent Composition: C 31.15%, H 6.53%, O 20.74%, S 41.58%
Line Formula: HSCH2(CHOH)2CH2SH
Literature References: Prepn: Evans et al., J. Chem. Soc. 1949, 253.
Properties: Slightly hygroscopic needles from ether, mp 42-43°. Can be sublimed at 37° and 0.005 mm press; bp2 125-130°. Redox potential: -0.33 volts at pH 7. Freely sol in water, ethanol, acetone, ethyl acetate, chloroform, ether.
Melting point: mp 42-43°
Boiling point: bp2 125-130°
Use: Protective agent for SH groups: Cleland, Biochemistry 3, 480 (1964), see also "Cleland's Reagent" a detailed brochure and bibliography published by Calbiochem, Los Angeles.

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