2,4,5-Trichlorophenol
Title: 2,4,5-Trichlorophenol
CAS Registry Number: 95-95-4
Additional Names: Collunosol
Trademarks: Dowicide 2 (Dow)
Molecular Formula: C6H3Cl3O
Molecular Weight: 197.45
Percent Composition: C 36.50%, H 1.53%, Cl 53.87%, O 8.10%
Literature References: Prepd by treating 1,2,4,5-tetrachlorobenzene with methanolic NaOH in autoclave at 160° for several hrs: Harrison et al., J. Chem. Soc. 1943, 235; Agfa, DE 411052 (1925); Chem. Zentralbl. 1925, I, 2411. Toxicity data: Deichmann, Fed. Proc. 2, 76 (1943). Review of toxicology and human exposure: Toxicological Profile for Chlorophenols (PB99-166639, 1999) 260 pp.
Properties: Needles from alcohol or ligroin. Strong phenolic odor. mp 67°. Sublimes. bp746 248°. bp760 253°. Weak monobasic acid. pK (25°) 7.37. Soly (g/100 g of solvent at 25°): acetone 615; benzene 163; carbon tetrachloride 51; ether 525; denatured alcohol formula 30, 525; methanol 615; liquid petrolatum (at 50°) 56; soybean oil 79; toluene 122; water <0.2. LD50 orally in rats: 0.82 g/kg (Deichmann).
Melting point: mp 67°
Boiling point: bp746 248°; bp760 253°
pKa: pK (25°) 7.37
Toxicity data: LD50 orally in rats: 0.82 g/kg (Deichmann)
 
Derivative Type: Sodium salt sesquihydrate
Trademarks: Dowicide B (Dow)
Literature References: Prepn: US 1991329 (1935 to Dow).
Properties: Flakes. Solubility (g/100 g solvent at 25°); acetone 163; denatured alcohol formula 30, 186; ethylene glycol 33; methanol 241; water 113. pH of satd aq soln 11.0-13.0.
 
Use: Fungicide, bactericide, biocide; intermediate in production of herbicides.

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