3',3'',5',5''-Tetrabromophenolphthalein
Title: 3¢,3¢¢,5¢,5¢¢-Tetrabromophenolphthalein
CAS Registry Number: 76-62-0
CAS Name: 3,3-Bis(3,5-dibromo-4-hydroxyphenyl)-1(3H)-isobenzofuranone
Molecular Formula: C20H10Br4O4
Molecular Weight: 633.91
Percent Composition: C 37.89%, H 1.59%, Br 50.42%, O 10.10%
Literature References: Prepd by direct bromination of phenolphthalein: Blicke et al., J. Am. Chem. Soc. 54, 1465 (1932). Diagnostic use: E. A. Graham, W. H. Cole, J. Am. Med. Assoc. 250, 2975 (1984), reprint of J. Am. Med. Assoc. 82, 613 (1924).
Properties: Crystals from alcohol, glacial acetic acid, or ether, mp 295-297° (dec). Practically insol in water. Slightly sol in alc, glacial acetic acid; sol in ether, in alkali with a violet color.
Melting point: mp 295-297° (dec)
 
Derivative Type: Disodium salt
CAS Registry Number: 860-07-1
Additional Names: Tetrabromophenolphthalein sodium
Trademarks: Brom-Tetragnost; Cholegnostyl; Tetrabrom
Molecular Formula: C20H8Br4Na2O4
Molecular Weight: 677.87
Percent Composition: C 35.44%, H 1.19%, Br 47.15%, Na 6.78%, O 9.44%
Properties: Blue crystals, dec on exposure to air becoming partially insol. Freely sol in water; slightly sol in alcohol. Insol in ether. pH of aq soln is 9-10. Keep well closed and protected from light.
 
Therap-Cat: Disodium salt as diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).

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