3'-Cytidylic Acid
Title: 3¢-Cytidylic Acid
CAS Registry Number: 84-52-6
Additional Names: Cytidine-3¢-monophosphate; cytidylic acid b; 3¢-cytidinephosphoric acid; cytidine-3¢-phosphate; 3¢-cytosylic acid; 3¢-CMP
Molecular Formula: C9H14N3O8P
Molecular Weight: 323.20
Percent Composition: C 33.45%, H 4.37%, N 13.00%, O 39.60%, P 9.58%
Literature References: Ribonuclease inhibitor. Prepn from yeast ribonucleic acid: see refs under 2¢-Cytidylic Acid. Prepn by pancreatic-ribonuclease-catalyzed ring opening of dicyclohexylguanidinium cytidine 2¢,3¢-cyclic phosphate: Lohrmann, Khorana, J. Am. Chem. Soc. 86, 4188 (1964). X-ray analysis studies of orthorhombic form: Alver, Furberg, Acta Chem. Scand. 13, 910 (1959); Sundaralingam, Jensen, J. Mol. Biol. 13, 914 (1965); of monoclinic form: Bugg, Marsh, ibid. 25, 67 (1967). Reviews: See Cytidine.
Properties: Crystals, dec 232-234°. [a]D20 +49.4° (c = 1 in water). [a]D25 +50.0° (c = 1 in aq NaOH adjusted to pH 10). uv max at pH 2: 279 nm (e 13.0); at pH 12: 272 nm (e 8.90). pKa1 0.8; pKa2 4.28; pKa3 6.0. Moderately sol in water; more sol than 2¢-cytidylic acid.
pKa: pKa1 0.8; pKa2 4.28; pKa3 6.0
Optical Rotation: [a]D20 +49.4° (c = 1 in water); [a]D25 +50.0° (c = 1 in aq NaOH adjusted to pH 10)
Absorption maximum: uv max at pH 2: 279 nm (e 13.0); at pH 12: 272 nm (e 8.90)

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