Title: 3-Methoxy-4-hydroxyphenylglycol
CAS Registry Number: 534-82-7
CAS Name: 1-(4-Hydroxy-3-methoxyphenyl)-1,2-ethanediol
Additional Names: (4-hydroxy-3-methoxyphenyl)ethylene glycol; vanylglycol; MHPG
Molecular Formula: C9H12O4
Molecular Weight: 184.19
Percent Composition: C 58.69%, H 6.57%, O 34.75%
Literature References: Major metabolite of norepinephrine, q.v. Isoln from rat urine: J. Axelrod et al., Biochim. Biophys. Acta 36, 576 (1959); from cat liver and kidney: M. Goldstein, S. B. Gertner, Nature 187, 147 (1960). Metabolism studies on urinary MHPG levels in patients with affective disorders: K. Greenspan et al., J. Psychiatr. Res. 7, 171 (1970); J. W. Maas et al., Biochem. Pharmacol. 1974, Suppl., pt. 2, 907; J. J. Schildkraut et al., Biol. Markers Psychiatry Neurol., Proc. Conf. 1981, E. Usdin, I. Hanin, Eds. (Pergamon, Oxford, 1982) pp 23-33. Studies on MHPG levels in cerebrospinal fluid (CSF): E. Garelis et al., Brain Res. 79, 1 (1974); P. Frattini et al., Clin. Chim. Acta 125, 97 (1982); in CSF of patients with CNS disorders: T. N. Chase et al., J. Neurochem. 21, 581 (1973); M. G. Ziegler et al., Am. J. Psychiatry 134, 565 (1977). Direct method to estimate rate of prodn of MHPG by human brain in vivo: J. W. Maas et al., Science 205, 1025 (1979). Review of origin and distribution in body fluids: E. M. DeMet, A. E. Halaris, Biochem. Pharmacol. 28, 3043-3050 (1979). Use as biochemical marker to identify mental disorders: T. H. Maugh, Science 214, 39 (1981).
Use: As biochemical tool.

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