4,4'-Methylenebis[2-chloroaniline]
Title: 4,4¢-Methylenebis[2-chloroaniline]
CAS Registry Number: 101-14-4
CAS Name: 4,4¢-Methylenebis[2-chlorobenzenamine]
Additional Names: 4,4¢-diamino-3,3¢-dichlorodiphenylmethane; di-(4-amino-3-chlorophenyl)methane; methylenebis(o-chloroaniline); MOCA; MBOCA; DACPM
Molecular Formula: C13H12Cl2N2
Molecular Weight: 267.15
Percent Composition: C 58.45%, H 4.53%, Cl 26.54%, N 10.49%
Literature References: Prepn: Finger, J. Prakt. Chem. [2] 79, 493 (1909); Mayer, Ber. 47, 1161 (1914). Acute toxicity: G. Ya. Kel'man et al., Kauch. Rezina 26(9), 28 (1967), C.A. 67, 120013m (1967). Review of carcinogenicity studies: IARC Monographs vol. 4, 65-71 (1974); of toxicology and human exposure: Toxicological Profile for 4,4¢-Methylenebis(2-chloroaniline) (PB95-100186, 1994) 146 p.
Properties: Flakes from alcohol, mp 110°. Slightly sol in water; sol in dil acids, ether, alcohol. LD50 orally in mice: 880 mg/kg (Kel'man).
Melting point: mp 110°
Toxicity data: LD50 orally in mice: 880 mg/kg (Kel'man)
CAUTION: Potential symptoms of overexposure are hematuria, cyanosis, nausea, methemoglobinemia, kidney irritation. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 206. This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-167.
Use: Curing agent for polyurethane and epoxy resins. Research tool for studying carcinogens.

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