Alsactide
Title: Alsactide
CAS Registry Number: 34765-96-3
CAS Name: 1-b-Alanine-17-[N-(4-aminobutyl)-L-lysinamide]-a1-17-corticotropin
Additional Names: 1-b-alanine-17-[L-2,6-diamino-N-(4-aminobutyl)hexanamide]-a1-17-corticotropin; [b-ala1,lys17]corticotropin-(1-17)-heptadecapeptide-4-amino-N-butylamide; [b-ala1,lys17]ACTH1-17-4-amino-N-butylamide; alisactide
Manufacturers' Codes: HOE-433
Trademarks: Synchrodyn (Hoechst)
Molecular Formula: C99H155N29O21S
Molecular Weight: 2119.54
Percent Composition: C 56.10%, H 7.37%, N 19.16%, O 15.85%, S 1.51%
Literature References: Short-chain ACTH analog. Synthesis: R. Geiger, H. G. Schroeder, DE 1954794; eidem, US 3749704 (1971, 1973, both to Hoechst); R. Geiger, Ann. 750, 165 (1971). Pharmacology: J. Sandow et al., Arch. Pharmacol. 297, Suppl. 2, R41 (1977). Dose dependent effects on cortisol and aldosterone plasma levels in man: A. Angeli et al., Horm. Metab. Res. 13, 24 (1981). Review of chronobiological activity: idem et al., Chronobiologica 14, 99-143 (1987).
 
Derivative Type: Acetate
CAS Registry Number: 33194-27-3
Line Formula: C99H155N29O21S.xC2H4O2
Properties: [a]D20 -68.6° (c = 0.5 in 1% acetic acid).
Optical Rotation: [a]D20 -68.6° (c = 0.5 in 1% acetic acid)
 
Therap-Cat: Diagnostic aid (adrenal function).
Keywords: Diagnostic Aid.

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