Title: Bazedoxifene
CAS Registry Number: 198481-32-2
CAS Name: 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-o1
Additional Names: 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
Molecular Formula: C30H34N2O3
Molecular Weight: 470.60
Percent Composition: C 76.57%, H 7.28%, N 5.95%, O 10.20%
Literature References: Nonsteroidal selective estrogen receptor modulator (SERM). Prepn: C. P. Miller et al., EP 802183; eidem, US 5998402 (1997, 1999 both to American Home); C. P. Miller et al., J. Med. Chem. 44, 1654 (2001). Pharmacology and receptor binding study: B. S. Komm et al., Endocrinology 146, 3999 (2005). Clinical pharmacology: S. Ronkin et al., Obstet. Gynecol. 105, 1397 (2005). Review of development: B. S. Komm, C. R. Lyttle, Ann. N.Y. Acad. Sci. 949, 317-326 (2001); and therapeutic potential: C. Gruber, D. Gruber, Curr. Opin. Invest. Drugs 5, 1086-1093 (2004).
Properties: mp 98-102°.
Melting point: mp 98-102°
Derivative Type: Acetate
CAS Registry Number: 198481-33-3
Manufacturers' Codes: TSE-424; WAY-140424; WAY-TSE-424
Molecular Formula: C30H34N2O3.C2H4O2
Molecular Weight: 530.65
Percent Composition: C 72.43%, H 7.22%, N 5.28%, O 15.08%
Properties: Crystals from acetone + acetic acid, mp 174-178°.
Melting point: mp 174-178°
Therap-Cat: Antiosteoporotic.
Keywords: Antiosteoporotic; Selective Estrogen Receptor Modulator (SERM).

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