Benzpiperylon
Title: Benzpiperylon
CAS Registry Number: 53-89-4
CAS Name: 1,2-Dihydro-2-(1-methyl-4-piperidinyl)-5-phenyl-4-(phenylmethyl)-3H-pyrazol-3-one
Additional Names: 4-benzyl-1-(1-methyl-4-piperidyl)-3-phenyl-3-pyrazolin-5-one; 1-(N-methyl-4-piperidyl)-3-phenyl-4-benzyl-5-pyrazolone; benzpiperilone
Manufacturers' Codes: KB-95
Trademarks: Humedil (Cheminova); Telon (Novartis)
Molecular Formula: C22H25N3O
Molecular Weight: 347.45
Percent Composition: C 76.05%, H 7.25%, N 12.09%, O 4.60%
Literature References: Prepd from (N-methylpiperidyl)hydrazine and ethyl 2-benzyl-3-oxo-3-phenylpropionate: A. Ebnöther et al., Helv. Chim. Acta 42, 1201 (1959); E. Jucker et al., CH 346885, CH 346886 (1960 both to Sandoz), C.A. 58, 5696a,b (1963). See also: eidem, US 2903460 (1959 to Sandoz). Pharmacological properties, toxicity: A. Cerletti et al., Boll. Chim. Farm. 102, 602 (1963).
Properties: Crystals from ethanol, dec 181-183°. pK1 6.73, pK2 9.13. LD50 in mice, rats, rabbits (mg/kg): 160, 160, 83 i.v.; 1880, 2700, 1700 orally (Cerletti).
pKa: pK1 6.73, pK2 9.13
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): 160, 160, 83 i.v.; 1880, 2700, 1700 orally (Cerletti)
Therap-Cat: Analgesic; anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Pyrazolones.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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