Title: Bromoform
CAS Registry Number: 75-25-2
CAS Name: Tribromomethane
Molecular Formula: CHBr3
Molecular Weight: 252.73
Percent Composition: C 4.75%, H 0.40%, Br 94.85%
Literature References: Prepd from acetone and sodium hypobromite: Günther, Jahresber. Fortschr. Chem. 1887, 741 (Beilstein vol. 1, 68); Kergomard, Bull. Soc. Chim. Fr. 1961, 2360. Toxicity data: Kutob, Plaa, Toxicol. Appl. Pharmacol. 4, 354 (1962). Review of toxicology and human exposure: Toxicological Profile for Bromoform and Dibromochloromethane (PB2006-100001, 2005) 273 pp.
Properties: Heavy liquid; chloroform odor; sweetish taste. bp 149-150°. mp 7.5°. d415 2.9035. nD15 1.6005. Sol in about 800 parts water; miscible with alc, benzene, chloroform, ether, petr ether, acetone, oils. Gradually dec, acquiring a yellow color; air and light accelerate the decompn. May be preserved by the addition of 3-4% alc. d 2.6-2.7. Keep in well-closed containers, protected from light. Incompat. Caustic alkalies. LD50 s.c. in mice: 7.2 mmol/kg (Kutob, Plaa).
Melting point: mp 7.5°
Boiling point: bp 149-150°
Index of refraction: nD15 1.6005
Density: d415 2.9035; d 2.6-2.7
Toxicity data: LD50 s.c. in mice: 7.2 mmol/kg (Kutob, Plaa)
CAUTION: Potential symptoms of overexposure are irritation of skin, eyes and respiratory system; CNS depression; liver, kidney damage. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 34.
Use: In separating mixtures of minerals.
Therap-Cat: Has been used as sedative, hypnotic; antitussive.
Keywords: Antitussive; Sedative/Hypnotic.

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