Title: Caroxazone
CAS Registry Number: 18464-39-6
CAS Name: 2-Oxo-2H-1,3-benzoxazine-3(4H)-acetamide
Additional Names: 3-acetamide-4H-1,3-benzoxazin-2-one; 4H-3-methylcarboxamide-3-benzoxazine-2-one; 4H-3-carbamoylmethyl-1,3-benzoxazin-2-one
Manufacturers' Codes: FI-6654
Trademarks: Timostenil (Farmitalia)
Molecular Formula: C10H10N2O3
Molecular Weight: 206.20
Percent Composition: C 58.25%, H 4.89%, N 13.59%, O 23.28%
Literature References: Prepn: GB 1115759; L. Bernardi et al., US 3427313 (1965, 1969 both to Soc. Farma. Italia); and pharmacological properties: eidem, Experientia 24, 774 (1968). Pharmacology: G. K. Suchowsky, L. Pegrassi, Arzneim.-Forsch. 19, 643 (1969); G. K. Suchowsky et al., Eur. J. Pharmacol. 6, 327 (1969). Clinical study: S. Cecchini et al., J. Int. Med. Res. 6, 388 (1978).
Properties: Solid, mp 203-205°.
Melting point: mp 203-205°
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Bicyclics.
Status: This monograph has been retired and is no longer subject to revision or update.

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