Chlorisondamine Chloride
Title: Chlorisondamine Chloride
CAS Registry Number: 69-27-2
CAS Name: 4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium dichloride
Additional Names: 4,5,6,7-tetrachloro-2-(2-dimethylaminoethyl)-2-methylisoindolinium chloride methochloride; 4,5,6,7-tetrachloro-2-(2-dimethylaminoethyl)isoindoline dimethylchloride; N-[(2-dimethylammonium)ethyl]-4,5,6,7-tetrachloroisoindolinium dimethochloride; chlorisondamine dimethochloride; Ecolid
Molecular Formula: C14H20Cl6N2
Molecular Weight: 429.04
Percent Composition: C 39.19%, H 4.70%, Cl 49.58%, N 6.53%
Literature References: Nicotinic receptor antagonist of the ganglion blocking class. Prepn: Allen, Ocampo, J. Electrochem. Soc. 103, 452, 682 (1956); Huebner, US 3025294 (1962 to Ciba). Pharmacology: P. B. S. Clarke et al., Br. J. Pharmacol. 111, 397 (1994). Use in studies of neuronal nicotinic acetylcholine receptors: A. S. Woods et al., J. Proteome Res. 2, 207 (2003).
Properties: Non-hygroscopic crystals contg ethanol of crystallization, mp 258-265° (dec). Sol in water, methanol, ethanol. pH of aq solns 4.7 to 6.2. Forms yellow, chloroform-soluble complex with bromcresol green, absorption max 420 nm.
Melting point: mp 258-265° (dec)
Absorption maximum: absorption max 420 nm
Use: Biochemical probe in nicotinic receptor studies.

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