Title: Clofoctol
CAS Registry Number: 37693-01-9
CAS Name: 2-[(2,4-Dichlorophenyl)methyl]-4-(1,1,3,3-tetramethylbutyl)phenol
Additional Names: a-(2,4-dichlorophenyl)-4-(1,1,3,3-tetramethylbutyl)-o-cresol
Trademarks: Gramplus (Chiesi); Octofene (HMR)
Molecular Formula: C21H26Cl2O
Molecular Weight: 365.34
Percent Composition: C 69.04%, H 7.17%, Cl 19.41%, O 4.38%
Literature References: Prepn: J. Debat, US 3830852 (1974 to Inst. Recherches Chim. Biol. Appl.). Activity against gram positive and gram negative bacteria: A. Buogo, Drugs Exp. Clin. Res. 10, 321 (1984). Pharmacokinetics in rats: M. Del Tacca et al. in Recent Advances in Chemotherapy, Antimicrobial Section 3, J. Ishigami, Ed. (University of Tokyo Press, 1985) pp 1927-28; in man: eidem, J. Antimicrob. Chemother. 19, 679 (1987). Mechanism of action: J. Combe et al., J. Pharmacol. 11, 411 (1980); F. Yablonsky, G. Simonet, ibid. 13, 515 (1982). Clinical trials in respiratory infections: J. Vialatte, Diagnostics 207, 65 (1978); in infectious bronchopulmonary diseases: R. Danesi, M. Del Tacca, Int. J. Clin. Pharmacol. Res. 5, 175 (1985); in ear, nose and throat infections: P. L. Ghilardi, A. Casani, Drugs Exp. Clin. Res. 11, 815 (1985).
Properties: Crystals from petr ether, mp 78°. LD50 orally in male rats: >4 g/kg (Debat).
Melting point: mp 78°
Toxicity data: LD50 orally in male rats: >4 g/kg (Debat)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic).

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