Cloprednol
Title: Cloprednol
CAS Registry Number: 5251-34-3
CAS Name: (11b)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
Additional Names: 6-chloro-D1,4,6-pregnatriene-11b,17a,21-triol-3,20-dione
Manufacturers' Codes: RS-4691
Trademarks: Cloradryn (Recordati); Novacort (Syntex); Syntestan (Syntex)
Molecular Formula: C21H25ClO5
Molecular Weight: 392.87
Percent Composition: C 64.20%, H 6.41%, Cl 9.02%, O 20.36%
Literature References: Prepn: H. J. Ringold, G. Rosenkranz, FR 1271981 C.A. 58, 1148a (1963); eidem, US 3232965 (1962, 1966 both to Syntex). Metabolic effects: E. Ortega et al., J. Clin. Pharmacol. 16, 122 (1976). Effects on hypothalamic-pituitary-adrenal axis function: eidem, J. Int. Med. Res. 4, 326 (1976). Bioavailability in humans: E. Mroszczak et al., J. Pharm. Sci. 67, 920 (1978). HPLC determn in plasma: C. Lee et al., ibid. 70, 669 (1981).
Properties: Crystals from acetone/hexane.
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.

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