Closantel
Title: Closantel
CAS Registry Number: 57808-65-8
CAS Name: N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
Manufacturers' Codes: R-31520
Trademarks: Flukiver (Janssen); Seponver (Ethnor)
Molecular Formula: C22H14Cl2I2N2O2
Molecular Weight: 663.07
Percent Composition: C 39.85%, H 2.13%, Cl 10.69%, I 38.28%, N 4.22%, O 4.83%
Literature References: Salicylanilide derivative. Prepn: M. A. C. Janssen, V. K. Sipido, BE 839481; eidem, US 4005218 (1976, 1977 both to Janssen). Effectiveness against Taenia pisiformis in rabbits: R. A. F. Chevis et al., Vet. Parasitol. 7, 333 (1980); against Ancylostoma caninum: J. Guerrero et al., J. Parasitol. 68, 616 (1983); against Fasciola hepatica in sheep: B. E. Stromberg et al., ibid. 70, 446 (1984). Prolonged effect on Haemonchus contortus in sheep: C. A. Hall et al., Res. Vet. Sci. 31, 104 (1981). Acts by uncoupling oxidative phosphorylation: H. Van den Bossche et al., Arch. Int. Physiol. Biochim. 87, 851 (1979); H. J. Kane et al., Mol. Biochem. Parasitol. 1, 347 (1980).
Properties: Crystals from methanol, mp 217.8°.
Melting point: mp 217.8°
Therap-Cat-Vet: Anthelmintic.

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