Colloidal Bismuth Subcitrate
Title: Colloidal Bismuth Subcitrate
CAS Registry Number: 57644-54-9
Additional Names: CBS
Trademarks: De-Nol (Yamanouchi); De-Noltab (Yamanouchi); Duosol (Interdelta); Ulcerone (Yamanouchi)
Literature References: Cytoprotective, polymeric bismuth citrato complex; also known as tripotassium dicitrato bismuthate. General prepn of colloidal bismuth solution: L. Vanino, cited in Mellor's vol. IX, 598 (1929). Manufacturing processes: C. J. McLoughlin, R. B. Himstedt, DE 2501787; P. J. H. Bos et al., EP 75992; eidem, US 4801608 (1975, 1985, 1989 all to Gist-Brocades). Analytical study: D. R. Williams, J. Inorg. Nucl. Chem. 39, 711 (1977). Crystal structure: E. Asato et al., Chem. Lett. 1992, 1967. Pharmacology: J. Wieriks et al., Scand. J. Gastroenterol. 17, Suppl. 80, 11 (1982). Modes of action: D. W. R. Hall, ibid. 24, Suppl. 157, 3 (1989); S. P. Lee, ibid. 26, Suppl. 185, 1 (1991). Pharmacokinetics and safety: L. Z. Benet ibid. 29. Symposia on pharmacology and clinical efficacy: ibid. 21, Suppl. 122, 1-54 (1986); Digestion 37, Suppl. 2, 1-64 (1987). Clinical trials in Helicobacter pylori associated gastritis and ulcer: T. Rokkas et al., Gut 29, 1386 (1988); W. A. de Boer et al., Am. J. Gastroenterol. 89, 1993 (1994).
Properties: White, amorphous powder. Sol in water, dil alkali, ammonia. Forms precipitate of bismuth oxychloride and bismuth citrate at pH <5.
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative.

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