Title: Cromolyn
CAS Registry Number: 16110-51-3
CAS Name: 5,5¢-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid]
Additional Names: 5,5¢-[(2-hydroxytrimethylene)dioxy]bis(4-oxo-4H-1-benzopyran-2-carboxylic acid); 5,5¢-(2-hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic acid); 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane; 1,3-di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol; cromoglycic acid
Molecular Formula: C23H16O11
Molecular Weight: 468.37
Percent Composition: C 58.98%, H 3.44%, O 37.58%
Literature References: Chromone complex which blocks mast cell degranulation. Prepn: NL 6603997; C. Fitzmaurice, T. B. Lee, US 3419578 (1966, 1968 both to Fisons). Metabolism: M. J. Ashton et al., Toxicol. Appl. Pharmacol. 26, 319 (1973). Mechanism of action: T. C. Theoharides et al., Science 207, 80 (1980); R. G. Alvarez et al., Agents Actions 11, 94 (1981). Toxicology in primates: J. E. Beach et al., Toxicol. Appl. Pharmacol. 57, 367 (1981). Clinical study in allergic conjunctivitis: G. A. Friday et al., Am. J. Ophthalmol. 95, 169 (1983). Review of pharmacology and clinical use: G. G. Shapiro, P. Konig, Pharmacotherapy 5, 156-170 (1985). Review: J. S. G. Cox in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 277-310; W. Storms, M. A. Kaliner, J. Asthma 42, 79-89 (2005).
Properties: mp 241-242° (dec).
Melting point: mp 241-242° (dec)
Derivative Type: Monohydrate
Properties: Colorless crystals from ethanol + ether, mp 216-217° (dec).
Melting point: mp 216-217° (dec)
Derivative Type: Disodium salt
CAS Registry Number: 15826-37-6
Additional Names: Cromolyn sodium; disodium cromoglycate; DSCG
Manufacturers' Codes: FPL-670
Trademarks: Alloptrex (Fabre); Allergocrom (Ursapharm); Colimune (Sanofi-Aventis); Cromabak (Th); Cromadoses (Th); Cromedil (Europhta); Cromogen (Ivax); Cromoptic (Chauvin); Duracroman (Merck KGaA); Gastrofrenal (Sigma-Tau); Hay-Crom (Ivax); Intal (Sanofi-Aventis); Intercron (Zambon); Lomudal (Sanofi-Aventis); Lomupren (Sanofi-Aventis); Lomusol (Sanofi-Aventis); Multicrom (Menarini); Nalcrom (Sanofi-Aventis); Nalcron (Sanofi-Aventis); Nasalcrom (Pharmacia & Upjohn); Ophtacalm (Chauvin); Opticrom (Sanofi-Aventis); Rynacrom (Sanofi-Aventis); Vividrin (Mann)
Molecular Formula: C23H14Na2O11
Molecular Weight: 512.33
Percent Composition: C 53.92%, H 2.75%, Na 8.97%, O 34.35%
Properties: Hygroscopic. Freely sol in water (100 mg/ml at 20°). Practically insol in chloroform and alcohol. LD50 in mice, rats (mg/kg): >8000 orally (Cox).
Toxicity data: LD50 in mice, rats (mg/kg): >8000 orally (Cox)
Therap-Cat: Antiasthmatic; antiallergic.
Therap-Cat-Vet: Antiallergic.
Keywords: Antiallergic; Antiasthmatic (Nonbronchodilator).

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