Title: Denileukin Diftitox
CAS Registry Number: 173146-27-5
CAS Name: N-L-Methionyl-387-L-histidine-388-L-alanine-1-388-toxin (Corynebacterium diphtheriae strain C7) (388®2¢)-protein with 2-133-interleukin 2 (human clone pTIL2-21a)
Additional Names: DAB389IL2
Manufacturers' Codes: LY-335348
Trademarks: Ontak (Ligand)
Literature References: Recombinant fusion protein consisting of the catalytic and translocation domains of diphtheria toxin fused to interleukin 2, q.v. Immunotoxin that selectively targets eukaryotic cells expressing the interleukin 2 receptor. Prepn: D. Williams et al., J. Biol. Chem. 265, 11885 (1990). Clinical evaluation in cutaneous T cell lymphoma: M. Duvic et al., Am. J. Hematol. 58, 87 (1998). Review of development and clinical experience: F. M. Foss et al., Curr. Top. Microbiol. Immunol. 234, 63-81 (1998).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Immunotoxins. |