Diatrizoate Sodium
Title: Diatrizoate Sodium
CAS Registry Number: 737-31-5
CAS Name: 3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid sodium salt
Additional Names: 3,5-diacetamido-2,4,6-triiodobenzoic acid sodium salt; sodium 3,5-diacetamido-2,4,6-triiodobenzoate; urografic acid sodium salt; sodium amidotrizoate; sodium diatrizoate
Trademarks: Hypaque Sodium (Winthrop); Triognost (Teva)
Molecular Formula: C11H8I3N2NaO4
Molecular Weight: 635.90
Percent Composition: C 20.78%, H 1.27%, I 59.87%, N 4.41%, Na 3.62%, O 10.06%
Literature References: Prepn of the acid: Larsen et al., J. Am. Chem. Soc. 78, 3210 (1956). Description: Langecker et al., Arch. Exp. Pathol. Pharmakol. 222, 584 (1954). Use in separation of leukocytes from whole blood: R. J. Perper et al., J. Lab. Clin. Med. 72, 842 (1968); L. P. Bignold, A. Ferrante, J. Immunol. Methods 96, 29 (1987); J. R. Kalmar et al., ibid. 110, 275 (1988). Comprehensive description: H. H. Lerner, Anal. Profiles Drug Subs. 4, 137-167 (1975).
Properties: Rhombic needles, slightly salty taste, mp 261-262° (dec). Soly in water at 20°: 60 g/100 ml. pH of a 50% aq soln 7.0 to 7.5. On chilling solns may become cloudy or form a precipitate which disappears at room temp. Solns may be sterilized by autoclaving. Should be protected from light. LD50 i.v. in rats: 14.7 g/kg (Langecker).
Melting point: mp 261-262° (dec)
Toxicity data: LD50 i.v. in rats: 14.7 g/kg (Langecker)
Derivative Type: Free acid
Properties: Crystals from dil DMF, mp >300°.
Melting point: mp >300°
NOTE: See also Meglumine Diatrizoate.
Use: Density gradient reagent for blood cell separation.
Therap-Cat: Diagnostic aid (radiopaque medium).
Therap-Cat-Vet: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).

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