Title: Diquafosol
CAS Registry Number: 59985-21-6
CAS Name: Uridine 5¢-(pentahydrogen tetraphosphate) P¢¢¢®5¢-ester with uridine
Additional Names: P1,P4-diuridine 5¢-tetraphosphate; UP4U
Molecular Formula: C18H26N4O23P4
Molecular Weight: 790.31
Percent Composition: C 27.36%, H 3.32%, N 7.09%, O 46.56%, P 15.68%
Literature References: Uridine nucleotide analog. P2Y2 purinoceptor agonist; stimulates mucin secretion from goblet cells. Prepn: M. J. Stutts, III et al., WO 9640059 (1996 to Univ. North Carolina at Chapel Hill); and receptor activity: W. Pendergast et al., Bioorg. Med. Chem. Lett. 11, 157 (2001). Ocular pharmacology: T. Fujihara et al., J. Ocul. Pharmacol. Ther. 18, 363 (2002). Review of development and therapeutic potential: J. Fischbarg, Curr. Opin. Invest. Drugs 4, 1377-1383 (2003); K. K. Nichols et al., Expert Opin. Invest. Drugs 13, 47-54 (2004). Clinical trial in dry eye disease: J. Tauber et al., Cornea 23, 784 (2004).
Derivative Type: Tetrasodium salt
CAS Registry Number: 211427-08-6
Manufacturers' Codes: INS-365
Molecular Formula: C18H22N4Na4O23P4
Molecular Weight: 878.23
Percent Composition: C 24.62%, H 2.52%, N 6.38%, Na 10.47%, O 41.90%, P 14.11%
Therap-Cat: In treatment of dry eye disease.
Keywords: Purinoceptor P2Y Agonist.

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