Title: Disulfamide
CAS Registry Number: 671-88-5
CAS Name: 4-Chloro-6-methyl-1,3-benzenedisulfonamide
Additional Names: 5-chlorotoluene-2,4-disulfonamide; 2-chloro-4-methylbenzene-1,5-disulfonamide; 5-chloro-2,4-disulfamyltoluene; disulphamide
Trademarks: Disamide (BDH); Natirene 25
Molecular Formula: C7H9ClN2O4S2
Molecular Weight: 284.74
Percent Composition: C 29.53%, H 3.19%, Cl 12.45%, N 9.84%, O 22.48%, S 22.52%
Literature References: Prepn: GB 851287 (1960 to Brit. Drug Houses). Pharmacology: David, Fellowes, J. Pharm. Pharmacol. 12, 65 (1960).
Properties: Non-hygroscopic cryst powder, mp 260°. uv max (ethanol): 285 nm (e 805). Practically insol in water. Slightly sol in ethanol. Soly in abs ethanol at 25° = 1.89% w/w; in 90% ethanol = 2.23% w/w; in isopropanol = 0.35%; in chloroform = 0.001%. Sol in cold NaOH solns.
Melting point: mp 260°
Absorption maximum: uv max (ethanol): 285 nm (e 805)
Therap-Cat: Diuretic.
Keywords: Diuretic; Sulfonamide Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update.

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