Dobesilate Calcium
Title: Dobesilate Calcium
CAS Registry Number: 20123-80-2
CAS Name: 2,5-Dihydroxybenzenesulfonic acid calcium salt
Additional Names: calcium dobesilate; hydroquinone calcium sulfonate
Trademarks: Dexium (Delalande); Doxium (Carrion)
Molecular Formula: C12H10CaO10S2
Molecular Weight: 418.41
Percent Composition: C 34.45%, H 2.41%, Ca 9.58%, O 38.24%, S 15.33%
Literature References: Prepn: ES 335945 (1967 to Labs. Esteve), C.A. 69, 106253z (1968); FR M6163; A. Esteve-Subirana, US 3509207 (1968, 1970 both to Labs. OM). Clinical trials: Berson, Praxis 59, 1305 (1970); 61, 52 (1972). Metabolism: A. Benakis et al., Therapie 29, 211 (1974).
Properties: White, powdery crystals from water, mp >300° (dec). Color deepens to pink upon exposure to air. Very soluble in water and alcohol. Practically insol in ether, benzene, chloroform. LD50 in mice: 700 mg/kg (Esteve-Subirana).
Melting point: mp >300° (dec)
Toxicity data: LD50 in mice: 700 mg/kg (Esteve-Subirana)
Therap-Cat: Vasotropic.
Keywords: Vasoprotectant.

Others monographs:
SorboseDasatinibChromic SulfatePildralazine
ProperdinDichlorodifluoromethaneAmmonium NitroferricyanideCalcium Arsenite
Matricarin2,4,5-TTallysomycinThallium Sesquioxide
©2016 DrugLead US FDA&EMEA