Title: EGCG
CAS Registry Number: 989-51-5
CAS Name: 3,4,5-Trihydroxybenzoic acid, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester
Additional Names: (-)-epigallocatechin 3-O-gallate; (-)-epigallocatechol gallate
Molecular Formula: C22H18O11
Molecular Weight: 458.37
Percent Composition: C 57.65%, H 3.96%, O 38.40%
Literature References: Polyphenolic constituent of tea; inhibits tumor promotion. Initial identification and isoln from green tea: M. Tsujimura, Bull. Agric. Chem. Soc. Jpn. 6, 70 (1930); C.A. 25, 3637 (1931); and crystallization: L. Vuataz et al., J. Chromatogr. 2, 173 (1959). Oxidation during tea fermentation: P. Coggon et al., J. Agric. Food Chem. 21, 727 (1973). HPLC/MS extraction from black tea: R. G. Bailey et al., J. Sci. Food Agric. 66, 203 (1994). HPLC determn in plasma and urine: M.-J. Lee et al., Cancer Epidemiol. Biomarkers Prev. 4, 393 (1995). Antitumor promoting activity: S. Yoshizawa et al., Phytother. Res. 1, 44 (1987); T. Yamane et al., Cancer Res. 55, 2081 (1995). Inhibition of metastasis in mice: S. Taniguchi et al., Cancer Lett. 65, 51 (1992). Modulation of endocrine systems and food intake: Y.-H. Kao, et al., Endocrinology 141, 980 (2000).
Properties: White crystals from water, mp 218°. [a]D -185 ±2°(ethanol). uv max (ethanol): 275 nm (e 11500).
Melting point: mp 218°
Optical Rotation: [a]D -185 ±2°(ethanol)
Absorption maximum: uv max (ethanol): 275 nm (e 11500)

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