Evan's Blue
Title: Evan's Blue
CAS Registry Number: 314-13-6
CAS Name: 6,6¢-[(3,3¢-Dimethyl[1,1¢-biphenyl]-4,4¢-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid] tetrasodium salt
Additional Names: C.I. Direct Blue 53; 4,4¢-bis[7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo]-3,3¢-bitolyl tetrasodium salt; C.I. 23860
Manufacturers' Codes: T-1824
Trademarks: Azovan Blue
Molecular Formula: C34H24N6Na4O14S4
Molecular Weight: 960.81
Percent Composition: C 42.50%, H 2.52%, N 8.75%, Na 9.57%, O 23.31%, S 13.35%
Literature References: Prepd by coupling 1 mol of diazotized o-tolidine with 2 mols of Chicago acid (1-amino-8-naphthol-2,4-disulfonic acid): DE 35341; DE 38802 Frdl. 1, 469, 488 (1877-1887); DE 3949; DE 57327; DE 75469 Frdl. 3, 685, 687, 690 (1890-1894); Hartwell, Fieser, Org. Synth. coll. vol. II, 145 (1943). Diagnostic use: M. H. Nielsen, N. C. Nielsen, Scand. J. Clin. Lab. Invest. 14, 605 (1962); O. Linderkamp et al., Eur. J. Pediatr. 125, 135 (1977).
Properties: Blue crystals with bronze to green luster. Sol in water, alcohol, acids, alkalies. Indicator changing color near pH 10. Destroyed by strong oxidizing and reducing agents and precipitated from soln by strong concns of neutral salts. Rather stable in aq soln, and may be autoclaved at 15 lbs pressure for 30 min. Dye made up in physiological saline should not be autoclaved.
Therap-Cat: Diagnostic aid (blood volume determination).
Keywords: Diagnostic Aid.

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