Fazadinium Bromide
Title: Fazadinium Bromide
CAS Registry Number: 49564-56-9
CAS Name: 1,1¢-Azobis[3-methyl-2-phenylimidazo[1,2-a]pyridinium] dibromide
Manufacturers' Codes: AH-8165
Trademarks: Fazadon (Glaxo Wellcome)
Molecular Formula: C28H24Br2N6
Molecular Weight: 604.34
Percent Composition: C 55.65%, H 4.00%, Br 26.44%, N 13.91%
Literature References: A short-acting curarimimetic with rapid onset. Prepn: D. Jack, E. E. Glover, DE 2127355; eidem, US 3773746 (1971, 1973 both to Allen & Hanburys); E. E. Glover, M. Yorke, J. Chem. Soc. C 1971, 3280. Pharmacology: L. Bolger et al., Nature 238, 354 (1972); and toxicity data: P. Bellani et al., Farmaco Ed. Sci. 39, 846 (1984). Clinical pharmacokinetics: T. Busi et al., Minerva Anestesiol. 49, 485 (1983). Clinical use: G. Minutella, G. Bongiovanni, ibid. 301; A. Lusini et al., ibid. 393.
 
Derivative Type: Dihydrate
Properties: Yellow crystals from water, mp 215-219° (softens at 196°). Also reported as yellow solid from methanol/ethyl acetate, mp 218-220°. uv max (H2O): 285, 297 nm (log e 4.04, 4.34). LD50 i.v. in rats: 1.5 mM/kg (Bellani).
Melting point: mp 215-219° (softens at 196°); mp 218-220°
Absorption maximum: uv max (H2O): 285, 297 nm (log e 4.04, 4.34)
Toxicity data: LD50 i.v. in rats: 1.5 mM/kg (Bellani)
 
Therap-Cat: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents.

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