Title: HNE
CAS Registry Number: 18286-49-2 (E-form); 29343-52-0 (undefined)
CAS Name: (2E)-4-Hydroxy-2-nonenal
Additional Names: 4-HNE
Molecular Formula: C9H16O2
Molecular Weight: 156.22
Percent Composition: C 69.19%, H 10.32%, O 20.48%
Literature References: Toxic aldehyde formed during lipid peroxidation in response to oxidative stress. Reacts primarily with the amino acids His or Lys to form an adduct which may alter protein function. Increased levels of the HNE-adduct are seen in Alzheimer's disease and after ozone exposure. Identification of cytotoxic activity of lipid oxidative products: E. Schauenstein, H. Esterbauer, Monatsh. Chem. 94, 164 (1963). Prepn: H. Esterbauer, W. Weger, ibid. 98, 1994 (1967). Synthesis: H. W. Gardner et al., Lipids 27, 686 (1992). Quantitative analysis by uv, GC/MS, HPLC: M. Kinter in Free Radicals N. A. Punchard, F. J. Kelly, Eds. (IRL Press, Oxford, UK, 1996) pp 133-145. Cytotoxicity: A. Benedetti et al., Biochim. Biophys. Acta 620, 281 (1980). Structural definition of adduct sites: D. V. Nadkarni, L. M. Sayre, Chem. Res. Toxicol. 8, 284 (1995); by MS: M. S. Bolgar, S. J. Gaskell, Anal. Chem. 68, 2325 (1996). Ozone-induced formation: A. Kirichenko et al., Toxicol. Appl. Pharmacol. 141, 416 (1996). Role in Alzheimer's disease: R. J. Mark et al., J. Neurochem. 68, 255 (1997); L. M. Sayre et al., ibid. 2092.
Properties: bp0.4 torr 84-87°. nD 1.471. d420 0.944. uv max (water): 447 nm; (ethanol) 452.5 nm; (hexane) 465 nm (e 13750, 13100, 14400). Soly at 20° (g/l): water 6.6. Partition coefficient K20 (H2O/CHCl3): 0.04.
Boiling point: bp0.4 torr 84-87°
Index of refraction: nD 1.471
Log P: Partition coefficient K20 (H2O/CHCl3): 0.04
Absorption maximum: uv max (water): 447 nm; (ethanol) 452.5 nm; (hexane) 465 nm (e 13750, 13100, 14400)
Density: d420 0.944

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