Iocarmic Acid
Title: Iocarmic Acid
CAS Registry Number: 10397-75-8
CAS Name: 3,3¢-[(1,6-Dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-5-[(methylamino)carbonyl]benzoic acid]
Additional Names: 5,5¢-(adipoyldiimino)bis[2,4,6-triiodo-N-methylisophthalamic acid]
Trademarks: Myelotrast (Winthrop)
Molecular Formula: C24H20I6N4O8
Molecular Weight: 1253.86
Percent Composition: C 22.99%, H 1.61%, I 60.73%, N 4.47%, O 10.21%
Literature References: Prepn: GB 1033695; US 3290366 (both 1966 to Mallinckrodt); G. B. Hoey et al., J. Med. Chem. 9, 964 (1966). Clinical studies: Kunze, Schiefer, Dtsch. Med. Wochenschr. 97, 245 (1972). Diagnostic use in myelography: P. Ahlgren, Acta Radiol. Diagn. 13, 753 (1972); in hysterosalpingography: H. E. Schutte, Diagn. Imaging 51, 277 (1982). Spinal toxicity in rats: I. O. Skalpe, A. Torvik, Invest. Radiol. 10, 154 (1975).
Properties: Crystals from dimethylformamide, mp 302° (dec).
Melting point: mp 302° (dec)
Derivative Type: Di-N-methylglucamine salt
CAS Registry Number: 54605-45-7
Additional Names: Dimeglumine iocarmate
Manufacturers' Codes: LM-280
Trademarks: Dimeray (Mallinckrodt); Dimer-X (Byk Gulden); Dirax (Daiichi)
Molecular Formula: C38H54I6N6O18
Molecular Weight: 1644.29
Percent Composition: C 27.76%, H 3.31%, I 46.31%, N 5.11%, O 17.51%
Properties: Soly in water (25°): 65 g/100 ml.
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).

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