Title: Ketotifen
CAS Registry Number: 34580-13-7
CAS Name: 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
Molecular Formula: C19H19NOS
Molecular Weight: 309.43
Percent Composition: C 73.75%, H 6.19%, N 4.53%, O 5.17%, S 10.36%
Literature References: Prepn: J. P. Bourquin et al., DE 2111071; eidem, US 3682930 (1971, 1972 both to Sandoz); E. Waldvogel et al., Helv. Chim. Acta 59, 866 (1976). Pharmacology: U. Martin, D. Roemer, Arzneim.-Forsch. 28, 770 (1978). Clinical studies: B. Wüthrick, P. Radielovic, Dtsch. Med. Wochenschr. 103, 1865 (1978); H. Gmür, M. Scherrer, Schweiz. Med. Wochenschr. 109, 881 (1979). Review: U. Martin et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 3, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 424-460. Review of clinical experience in asthma and allergy: S. M. Grant et al., Drugs 40, 412-448 (1990).
Properties: Crystals from ethyl acetate, mp 152-153°.
Melting point: mp 152-153°
Derivative Type: Fumarate
CAS Registry Number: 34580-14-8
Manufacturers' Codes: HC-20511
Trademarks: Totifen (Chiesi); Zaditen (Novartis); Zaditor (Novartis); Zasten (Novartis)
Molecular Formula: C19H19NOS.C4H4O4
Molecular Weight: 425.50
Percent Composition: C 64.92%, H 5.45%, N 3.29%, O 18.80%, S 7.54%
Properties: Crystals, mp 192° (dec).
Melting point: mp 192° (dec)
Therap-Cat: Antiasthmatic; antiallergic.
Keywords: Antiasthmatic (Nonbronchodilator); Antiallergic.

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