Lotrifen
Title: Lotrifen
CAS Registry Number: 66535-86-2
CAS Name: 2-(4-Chlorophenyl)-(1,2,4)triazolo[5,1-a]isoquinoline
Additional Names: 2-(p-chlorophenyl)-s-triazolo[5,1-a]isoquinoline
Manufacturers' Codes: L-12717; DL-717-IT
Trademarks: Canocenta (Byk Gulden); Privaprol (Lepetit)
Molecular Formula: C16H10ClN3
Molecular Weight: 279.72
Percent Composition: C 68.70%, H 3.60%, Cl 12.67%, N 15.02%
Literature References: Non-hormonal antifertility agent. Prepn: BE 815498; A. Omodei-Salé et al., US 4075341 (1974, 1978 both to Lepetit). Pharmacokinetics: G. GalliZani et al., J. Pharmacobio-Dyn. 5, 55 (1981). Pregnancy-terminating effect in dogs: G. Galliani, A. Omodei-Salé, J. Small Anim. Pract. 23, 295 (1982). Effect on subsequent fertility: G. Galliani et al., IRCS Med. Sci. 12, 433, 435 (1984). Review: A. Assandri et al., Rev. Drug Metab. Drug Interact. 4, 237 (1982).
Properties: Crystals mp 238-240°.
Melting point: mp 238-240°
Therap-Cat-Vet: Abortifacient.

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