Title: Lubeluzole
CAS Registry Number: 144665-07-6
CAS Name: (aS)-4-(2-Benzothiazolylmethylamino)-a-[(3,4-difluorophenoxy)methyl]-1-piperidineethanol
Manufacturers' Codes: R-87926
Trademarks: Prosynap (Janssen)
Molecular Formula: C22H25F2N3O2S
Molecular Weight: 433.51
Percent Composition: C 60.95%, H 5.81%, F 8.76%, N 9.69%, O 7.38%, S 7.40%
Literature References: Modulates the glutamate-activated nitric oxide synthase (NOS) pathway. Prepn: R. A. Stokbroekx, G. A. J. Grauwels, EP 501552; US 5434168 (1992, 1995 both to Janssen). Mechanism of action study: M. De Ryck et al., J. Pharmacol. Exp. Ther. 279, 748 (1996); A. S. Lesage et al., ibid. 759. Clinical pharmacokinetics: J. De Keyser et al., Clin. Ther. 19, 1340 (1997). Clinical trial in acute ischemic stroke: J. Grotta et al., Stroke 28, 2338 (1997).
Properties: Crystals from 2,2¢-oxybispropane, mp 65.8°. [a]D20 +4.38° (c = 1 in methanol).
Melting point: mp 65.8°
Optical Rotation: [a]D20 +4.38° (c = 1 in methanol)
Therap-Cat: Neuroprotective.
Keywords: Neuroprotective.

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