Mirtazapine
Title: Mirtazapine
CAS Registry Number: 61337-67-5
CAS Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Additional Names: 2-methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine; 6-azamianserin; mepirzepine
Manufacturers' Codes: Org-3770
Trademarks: Remeron (Organon); Zispin (Organon)
Molecular Formula: C17H19N3
Molecular Weight: 265.35
Percent Composition: C 76.95%, H 7.22%, N 15.84%
Literature References: a2-Adrenergic blocker; analog of mianserin, q.v. Prepn: W. J. Van der Burg, DE 2614406; idem, US 4062848 (1976, 1977 both to AKZO). GC determn in plasma: J. E. Paanakker, H. J. M. Van Hal, J. Chromatogr. 417, 203 (1987). Pharmacology and mechanism of action study: T. De Boer et al., Neuropharmacology 27, 399 (1988). Clinical comparison with amitriptyline, q.v.: W. T. Smith et al., Psychopharmacol. Bull. 26, 191 (1990). Review of clinical experience in mood and anxiety disorders: M. J. Ostacher et al., Expert Rev. Neurotherapeut. 3, 425-433 (2003); and of clinical pharmacokinetics, safety and efficacy: A. Szegedi, N. Schwertfeger, Expert Opin. Pharmacother. 6, 631-641 (2005).
Properties: White crystals from petr ether, mp 114-116°. Sol in methanol and chloroform.
Melting point: mp 114-116°
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tetracyclics.

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