Neridronic Acid
Title: Neridronic Acid
CAS Registry Number: 79778-41-9
CAS Name: (6-Amino-1-hydroxyhexylidene)bisphosphonic acid
Molecular Formula: C6H17NO7P2
Molecular Weight: 277.15
Percent Composition: C 26.00%, H 6.18%, N 5.05%, O 40.41%, P 22.35%
Literature References: Bisphosphonate antiresorptive agent. Prepn: J. Jary et al., BE 885139; eidem, US 4304734 (both 1981 to Vysoka Skola Chem.-Tech.); and characterization of monosodium salt: M. Neves et al., Nucl. Med. Biol. 29, 329 (2002). Crystal structure: V. M. Coiro, D. Lamba, Acta Crystallogr. C45, 446 (1989). Clinical study in Paget's disease: S. Adami et al., Clin. Exp. Rheumatol. 20, 55 (2002); in osteogenesis imperfecta: idem et al., J. Bone Miner. Res. 18, 126 (2003); in osteoporosis: V. Braga et al., Bone 33, 342 (2003).
Properties: mp 245°.
Melting point: mp 245°
 
Derivative Type: Monosodium salt
CAS Registry Number: 80729-79-9
Additional Names: Neridronate sodium
Trademarks: Nerixia (Abiogen)
Molecular Formula: C6H16NNaO7P2
Molecular Weight: 299.13
Percent Composition: C 24.09%, H 5.39%, N 4.68%, Na 7.69%, O 37.44%, P 20.71%
Properties: White solid, mp 263-266° (hemihydrate).
Melting point: mp 263-266° (hemihydrate)
 
Therap-Cat: Bone resorption inhibitor.
Keywords: Bone Resorption Inhibitor; Antiosteoporotic; Antipagetic.

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