Title: Niaprazine
CAS Registry Number: 27367-90-4
CAS Name: N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]-3-pyridinecarboxamide
Additional Names: N-[3-[4-(p-fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide
Trademarks: Nopron (Carrion)
Molecular Formula: C20H25FN4O
Molecular Weight: 356.44
Percent Composition: C 67.39%, H 7.07%, F 5.33%, N 15.72%, O 4.49%
Literature References: Prepn: R. Y. Mauvernay, DE 1957371 corresp to US 3712893 (1970, 1973 both to CERM). Pharmacology: P. Duchene-Marrullaz et al., Therapie 26, 1203 (1971). Psycholeptic effects in mice: J. Hache, J. Tachon, J. Pharmacol. 7, 469 (1976). Brain catecholamine depletion: P. E. Keane, M. S. Benedetti, Neuropharmacology 18, 595 (1979).
Properties: Cryst from ethyl acetate, mp 131°. Photosensitive. LD50 in mice (mg/kg): 890 orally, 145 i.v. (Mauvernay).
Melting point: mp 131°
Toxicity data: LD50 in mice (mg/kg): 890 orally, 145 i.v. (Mauvernay)
Therap-Cat: Sedative; hypnotic.
Keywords: Sedative/Hypnotic; Amides.

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