Title: Noxiptilin
CAS Registry Number: 3362-45-6
CAS Name: 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one O-[2-(dimethylamino)ethyl]oxime
Additional Names: 2-[[(10,11-dihydro-5H-dibenz[a,d]cyclohepten-5-ylidene)amino]oxy]-N,N-dimethylethylamine; 5-(2-dimethylaminoethyloximino)-5H-dibenzo[a,d]cyclohepta-1,4-diene; 5-[b-(dimethylamino)ethoxyimino]-10,11-dihydro-5H-dibenzo[a,d]cycloheptene; noxiptyline; dibenzoxin
Molecular Formula: C19H22N2O
Molecular Weight: 294.39
Percent Composition: C 77.52%, H 7.53%, N 9.52%, O 5.43%
Literature References: Prepn: Engelhard et al., DE 1198353 (1965); Schutz, Hoffmeister, DE 1225169; Schutz et al., US 3505321 (1966, 1970 both to Bayer); Wrigley, Leeming, GB 1045911 (1966 to Pfizer). Toxicity study: F. Hoffmeister et al., Arzneim.-Forsch. 19, 846 (1969). Series of articles on pharmacology, metabolism, clinical data: ibid. 458-467; 846-878.
Properties: Free base, bp0.05 160-164°.
Boiling point: bp0.05 160-164°
Derivative Type: Hydrochloride
CAS Registry Number: 4985-15-3
Manufacturers' Codes: Bay 1521
Trademarks: Agedal (Bayer); Nogédal (Thžaplix)
Molecular Formula: C19H22N2O.HCl
Molecular Weight: 330.85
Percent Composition: C 68.97%, H 7.01%, N 8.47%, O 4.84%, Cl 10.72%
Properties: Crystals from ethanol + ethyl acetate, mp 185-187°. LD50 s.c. in mice: 240 mg/kg (Hoffmeister).
Melting point: mp 185-187°
Toxicity data: LD50 s.c. in mice: 240 mg/kg (Hoffmeister)
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.
Status: This monograph has been retired and is no longer subject to revision or update.

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