Title: PPACK
CAS Registry Number: 71142-71-7
CAS Name: D-Phenylalanyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-L-prolinamide
Additional Names: D-phenylalanyl-prolyl-arginine chloromethyl ketone; FPRMeCl
Molecular Formula: C21H31ClN6O3
Molecular Weight: 450.96
Percent Composition: C 55.93%, H 6.93%, Cl 7.86%, N 18.64%, O 10.64%
Literature References: Selective irreversible inhibitor of thrombin: C. A. Kettner, E. N. Shaw, Thromb. Res. 14, 969 (1979). Synthesis: E. N. Shaw, C. A. Kettner, US 4318904 (1982 to Research Corp.). Anticoagulant and antithrombotic activity: J. Hauptman, F. Markwardt, Thromb. Res. 20, 347 (1980). In vivo studies: D. Collen et al., J. Lab. Clin. Med. 99, 76 (1982).
NOTE: Commercially available as the dihydrochloride.
Use: As a research tool; as a clinical reagent to measure the level of thrombin in blood.

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