Title: Pemirolast
CAS Registry Number: 69372-19-6
CAS Name: 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Molecular Formula: C10H8N6O
Molecular Weight: 228.21
Percent Composition: C 52.63%, H 3.53%, N 36.83%, O 7.01%
Literature References: Inhibitor of chemical mediator release from tissue mast cells. Prepn: P. F. Juby, US 4122274 (1978 to Bristol-Myers). LC determn in plasma: H. Cheng et al., J. Pharm. Sci. 76, 918 (1987). Immunopharmacology and mechanism of action studies: Y. Yanagihara et al., Jpn. J. Pharmacol. 48, 91, 103 (1988). Clinical evaluation in allergic rhinitis: D. G. Tinkelman, R. B. Berkowitz, Ann. Allergy 66, 162 (1991).
Properties: Crystals from DMF, mp 310-311° (dec).
Melting point: mp 310-311° (dec)
Derivative Type: Potassium salt
CAS Registry Number: 100299-08-9
Manufacturers' Codes: BMY-26517; TBX
Trademarks: Pemilaston (BMS)
Molecular Formula: C10H7KN6O
Molecular Weight: 266.30
Percent Composition: C 45.10%, H 2.65%, K 14.68%, N 31.56%, O 6.01%
Properties: Yellowish-white crystalline powder. Highly soluble in water.
Therap-Cat: Antiallergic.
Keywords: Antiallergic.

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