Picolinic Acid
Title: Picolinic Acid
CAS Registry Number: 98-98-6
CAS Name: 2-Pyridinecarboxylic acid
Additional Names: o-pyridinecarboxylic acid
Molecular Formula: C6H5NO2
Molecular Weight: 123.11
Percent Composition: C 58.54%, H 4.09%, N 11.38%, O 25.99%
Literature References: Naturally occuring isomer of nicotinic acid; by-product of tryptophan catabolism. Prepn: Singer, McElvain, Org. Synth. coll. vol. III, 740 (1955). Review: Oliveto, "Pyridinecarboxylic Acids" in Pyridine and Its Derivatives Part 3, E. Klingsberg, Ed. (Interscience, New York, 1962) p 179. Review of immunobiology and effect on macrophage activation: G. Melillo et al., Adv. Exp. Med. Biol. 398, 135-141 (1996). HPLC determn in biological fluids: C. Dazzi et al., J. Chromatogr. B 751, 61 (2001).
Properties: Needles from water, alcohol or benzene, mp 134-136°. pK 5.4. Sublimes. Very sol in glacial acetic acid; practically insol in ether, chloroform, carbon disulfide.
Melting point: mp 134-136°
pKa: pK 5.4
Derivative Type: Hydrochloride
Properties: Crystals from abs ethanol/ether, mp 210-212° (slow heating).
Melting point: mp 210-212° (slow heating)

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