Pimecrolimus
Title: Pimecrolimus
CAS Registry Number: 137071-32-0
CAS Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Additional Names: 33-epi-chloro-33-desoxyascomycin
Manufacturers' Codes: SDZ-ASM-981
Trademarks: Elidel (Novartis)
Molecular Formula: C43H68ClNO11
Molecular Weight: 810.45
Percent Composition: C 63.73%, H 8.46%, Cl 4.37%, N 1.73%, O 21.72%
Literature References: Macrolactam ascomycin derivative; inhibits production of pro-inflammatory cytokines by T cells and mast cells. Prepn: K. Baumann, G. Emmer, EP 427680 (1991 to Sandoz); eidem, US 5912238 (1999 to Novartis). In vitro pharmacology: M. Gassberger et al., Br. J. Dermatol. 141, 264 (1999). Clinical evaluation in psoriasis: U. Mrowietz et al., ibid. 139, 992 (1998); in contact dermatitis: C. Queille-Roussel et al., Contact Dermatitis 42, 349 (2000).
Therap-Cat: Immunosuppresant.
Keywords: Immunosuppressant.

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