Title: Sulconazole
CAS Registry Number: 61318-90-9
CAS Name: 1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Additional Names: (±)-1-[2,4-dichloro-b-[(p-chlorobenzyl)thio]phenethyl]imidazole
Molecular Formula: C18H15Cl3N2S
Molecular Weight: 397.75
Percent Composition: C 54.35%, H 3.80%, Cl 26.74%, N 7.04%, S 8.06%
Literature References: Prepn: K. A. M. Walker, DE 2541833; idem, US 4055652 (1976, 1977 both to Syntex). HPLC determn in plasma: M. Fass et al., J. Pharm. Sci. 70, 1338 (1981). Mechanism of action study: W. H. Beggs, Biochem. Arch. 10, 117 (1994). Clinical trial in tinea pedis: W. A. Akers et al., J. Am. Acad. Dermatol. 21, 686 (1989). Review of pharmacology and clinical efficacy: P. Benfield, S. P. Clissold, Drugs 35, 143-153 (1988).
Derivative Type: Nitrate
CAS Registry Number: 61318-91-0
Manufacturers' Codes: RS-44872
Trademarks: Exelderm (Syntex); Myk (Cassenne); Sulcosyn (Syntex)
Molecular Formula: C18H15Cl3N2S.HNO3
Molecular Weight: 460.76
Percent Composition: C 46.92%, H 3.50%, Cl 23.08%, N 9.12%, S 6.96%, O 10.42%
Properties: Colorless crystals from acetone, mp 130.5-132°.
Melting point: mp 130.5-132°
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.

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