Technetium 99mTc Apcitide
Title: Technetium 99mTc Apcitide
CAS Registry Number: 178959-14-3
Additional Names: 99mTc-P246
Trademarks: AcuTect (Diatide)
Literature References: Radiolabeled synthetic peptide that preferentially binds to glycoprotein GP IIb/IIIa receptors on the surface of activated platelets. Monomer designed as a scintigraphic imaging agent for detection and localization of acute deep vein thrombosis (DVT). Prepn: R. T. Dean, J. Lister-James, WO 9325244; eidem, US 5508020 (1993, 1996 both to Diatech); D. A. Pearson et al., J. Med. Chem. 39, 1372 (1996). Pharmacology and immunoscintigraphy: J. Lister-James et al., J. Nucl. Med. 37, 755 (1996). Clinical study in DVT: R. Taillefer et al., ibid. 41, 1214 (2000).
Derivative Type: Dimer
CAS Registry Number: 153507-46-1
Additional Names: Bibapcitide; P-280
Molecular Formula: C112H162N36O43S10
Molecular Weight: 3021.35
Percent Composition: C 44.52%, H 5.40%, N 16.69%, O 22.77%, S 10.61%
Literature References: Synthetic peptide consisting of 26 amino acids; exhibits the same GP IIb/IIIa binding activity as the monomer. Splits to form monomer upon reaction with sodium pertechnetate 99mTc, q.v.
Therap-Cat: Diagnostic aid (radioactive imaging agent).
Keywords: Diagnostic Aid (Radioactive Imaging Agent).

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