Terofenamate
Title: Terofenamate
CAS Registry Number: 29098-15-5
CAS Name: 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid ethoxymethyl ester
Additional Names: N-(2,6-dichloro-m-tolyl)anthranilic acid ethoxymethyl ester; etoclofene
Trademarks: Etofen (Lusofarmaco)
Molecular Formula: C17H17Cl2NO3
Molecular Weight: 354.23
Percent Composition: C 57.64%, H 4.84%, Cl 20.02%, N 3.95%, O 13.55%
Literature References: Anti-inflammatory deriv of anthranilic acid, q.v. Prepn: GB 1199386; E. Manghisi, US 3642864 (1970, 1972 both to Lusofarmaco); A. Salembeni et al., Farmaco Ed. Sci. 30, 276 (1975). Biological properties: G. B. Fregnan et al., ibid. 353. Absorption, distribution, excretion: eidem, Boll. Chim. Farm. 114, 85 (1975). Pharmacological and toxicity studies: T. Chieli et al., ibid. 115, 41 (1976).
Properties: Crystals from ethanol, mp 73-74°. LD50 in mice, rats (mg/kg): 918, 307 orally; 300, 274 i.p. (Chieli).
Melting point: mp 73-74°
Toxicity data: LD50 in mice, rats (mg/kg): 918, 307 orally; 300, 274 i.p. (Chieli)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Aminoarylcarboxylic Acid Derivatives.

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