Title: Thiambutene
CAS Registry Number: 86-14-6
CAS Name: N,N-Diethyl-1-methyl-3,3-di-2-thienylallylamine
Additional Names: 3-diethylamino-1,1-di(2¢-thienyl)but-1-ene; diethylthiambutene
Manufacturers' Codes: 191C49; NIH-4185
Molecular Formula: C16H21NS2
Molecular Weight: 291.47
Percent Composition: C 65.93%, H 7.26%, N 4.81%, S 22.00%
Literature References: Prepn: Adamson, J. Chem. Soc. 1950, 885; US 2561899 (1951 to Burroughs Wellcome). Toxicity data: J. S. McKenzie, N. R. Beechey, Arch. Int. Pharmacodyn. Ther. 135, 376 (1962). Use: Hayes, Vet. Rec. 83, 528 (1968). Evaluation as analgesic and preanesthetic agent: W. D. Harbison et al., Aust. Vet. J. 50, 543 (1974). HPLC determn: I. Jane et al., J. Chromatogr. 323, 191 (1985).
Properties: bp0.03 122-128°. LD50 i.p. in mice: 90 mg/kg (McKenzie, Beechey).
Boiling point: bp0.03 122-128°
Toxicity data: LD50 i.p. in mice: 90 mg/kg (McKenzie, Beechey)
Derivative Type: Hydrochloride
Trademarks: Themalon (Burroughs Wellcome)
Molecular Formula: C16H21NS2.HCl
Molecular Weight: 327.94
Percent Composition: C 58.60%, H 6.76%, N 4.27%, S 19.56%, Cl 10.81%
Properties: Crystals, mp 152-153°.
Melting point: mp 152-153°
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.11.
Therap-Cat-Vet: Analgesic (narcotic).

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