Tremorine
Title: Tremorine
CAS Registry Number: 51-73-0
CAS Name: 1,1¢-(2-Butyne-1,4-diyl)bispyrrolidine
Additional Names: 1,1¢-(2-butynylene)dipyrrolidine; 1,4-dipyrrolidino-2-butyne
Molecular Formula: C12H20N2
Molecular Weight: 192.30
Percent Composition: C 74.95%, H 10.48%, N 14.57%
Literature References: Prepn from pyrrolidine + 1,4-dichloro-2-butyne: Maier, DE 896810 (1953 to BASF); Reppe et al., Ann. 596, 79 (1955); Biel, DiPierro, J. Am. Chem. Soc. 80, 4609 (1958). Review of chemical and biological studies: Karlen, Acta Pharm. Suec. 1970, 169-200; see also Kolla, Obvintseva, Farmakol. Toksikol. 36, 736-745 (1973).
Properties: Liquid. bp2.5 116-116.5°; bp 0.1 93-95°.
Boiling point: bp2.5 116-116.5°; bp 0.1 93-95°
 
Derivative Type: Methiodide
Molecular Formula: C12H20N2.2CH3I
Molecular Weight: 476.18
Percent Composition: C 35.31%, H 5.50%, N 5.88%, I 53.30%
Properties: Crystals, mp 239-240°.
Melting point: mp 239-240°
 
Use: To produce exptl parkinsonism: Everett et al., Science 124, 79 (1956).

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