Valethamate Bromide
Title: Valethamate Bromide
CAS Registry Number: 90-22-2
CAS Name: N,N-Diethyl-N-methyl-2-[(3-methyl-1-oxo-2-phenylpentyl)oxy]ethanaminium bromide
Additional Names: 3-methyl-2-phenylvaleric acid diethyl(3-hydroxyethyl)methylammonium bromide ester; 2-phenyl-3-methylvaleric acid b-(diethylamino)ethyl ester bromomethylate; 3-methyl-2-phenylvaleric acid 2-diethylaminoethyl ester methyl bromide; 2-diethylaminoethyl 2-phenyl-3-methylvalerate methyl bromide; diethyl(2-hydroxyethyl)methylammonium 3-methyl-2-phenylvalerate bromide
Trademarks: Resitan (Takeda); Epidosin (Solvay)
Molecular Formula: C19H32BrNO2
Molecular Weight: 386.37
Percent Composition: C 59.06%, H 8.35%, Br 20.68%, N 3.63%, O 8.28%
Literature References: Anticholinergic. Prepn: Stühmer, Funke, DE 969245; DE 971136; DE 1112989 (all 1958 to Kali-Chemie); Martin, Habicht, DE 1091124; US 2987517 (1960, 1961 both to Cilag-Chemie).
Properties: Crystals from ethanol + ether or acetone, mp 100-101°. Freely sol in water, very sol in alcohol. Practically insol in ether. Aq solns are stable to storage; 0.6% ampuled solns showed no loss after one year at room temp.
Melting point: mp 100-101°
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic; Antimuscarinic.

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