Acetophenazine
Title: Acetophenazine
CAS Registry Number: 2751-68-0
CAS Name: 1-[10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]ethanone
Additional Names: 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]phenothiazin-2-yl methyl ketone; 2-acetyl-10-[3-[4-(b-hydroxyethyl)piperazinyl]propyl]phenothiazine; 1-(2-hydroxyethyl)-4-[3-(2-acetyl-10-phenothiazyl)propyl]piperazine
Molecular Formula: C23H29N3O2S
Molecular Weight: 411.56
Percent Composition: C 67.12%, H 7.10%, N 10.21%, O 7.78%, S 7.79%
Literature References: Prepd from 1-(2-hydroxyethyl)piperazine and 10-(3-chloropropyl)-2-acetylphenothiazine: Sherlock, Sperber, US 2985654 (1961 to Schering). Toxicity study: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972).
 
Derivative Type: Dimaleate
CAS Registry Number: 5714-00-1
Trademarks: Tindal (Schering)
Molecular Formula: C23H29N3O2S.2C4H4O4
Molecular Weight: 643.70
Percent Composition: C 57.84%, H 5.79%, N 6.53%, O 24.86%, S 4.98%
Properties: Crystals from ethanol, mp 167-168.5°. LD50 orally in rats: 433 mg/kg (Schafer).
Melting point: mp 167-168.5°
Toxicity data: LD50 orally in rats: 433 mg/kg (Schafer)
 
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.

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