Title: Ampligen
CAS Registry Number: 38640-92-5
CAS Name: 5¢-Inosinic acid homopolymer complex with 5¢-cytidylic acid polymer with 5¢-uridylic acid (1:1)
Additional Names: poly I . poly (C12U); poly(rI) . poly[r(C12U)n]; rIn . r(C12U)n
Literature References: Synthetic, mismatched double-stranded RNA capable of inducing interferons, q.v. Consists of a strand of 5¢-inosinic acid (I) units hydrogen bonded to a second strand of 5¢-cytidylic- (C) 5¢-uridylic- (U) acid units in a 12C:U ratio. Prepn and pharmacology: P. O. P. Ts'o et al., Mol. Pharmacol. 12, 299 (1976). Antiviral activity: W. A. Carter et al., ibid. 440; against HIV: D. C. Montefiori, W. M. Mitchell, Proc. Natl. Acad. Sci. USA 84, 2985 (1987); D. C. Montefiori et al., Antiviral Res. 9, 47 (1988). Induction of interferon: D. A. Stringfellow, S. D. Weed, Antimicrob. Agents Chemother. 17, 988 (1980). Mechanism of action study: W. G. Hearl, M. I. Johnston, Biochem. Biophys. Res. Commun. 138, 40 (1986). Antitumor effects in comparison with interferon: H. R. Hubbell et al., Cancer Res. 44, 3252 (1984); and immunomodulatory effects: H. R. Hubbell et al., ibid. 45, 2481 (1985); W. A. Carter et al., J. Biol. Response Modif. 4, 613 (1985). HPLC determn in plasma: M. G. Rosenblum, L. Cheung, J. Liq. Chromatogr. 9, 2869 (1986). Clinical evaluation in metastatic cancers: I. Brodsky et al., J. Biol. Response Modif. 4, 669 (1985). Clinical trial in chronic fatigue syndrome: D. R. Strayer et al., Clin. Infect. Dis. 18, Suppl. 1, S88 (1994); in treatment of HIV: K. A. Thompson et al., Eur. J. Clin. Microbiol. Infect. Dis. 15, 580 (1996).
Therap-Cat: Antiviral; immunomodulator.
Keywords: Immunomodulator; Antiviral; Polynucleotides.

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