Anileridine
Title: Anileridine
CAS Registry Number: 144-14-9
CAS Name: 1-[2-(4-Aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxylic acid ethyl ester
Additional Names: 1-(p-aminophenethyl)-4-phenylisonipecotic acid ethyl ester; ethyl 1-(4-aminophenethyl)-4-phenylisonipecotate; N-[b-(p-aminophenyl)ethyl]-4-phenyl-4-carbethoxypiperidine; N-b-(p-aminophenyl)ethylnormeperidine
Trademarks: Leritine (Merck & Co.)
Molecular Formula: C22H28N2O2
Molecular Weight: 352.47
Percent Composition: C 74.97%, H 8.01%, N 7.95%, O 9.08%
Literature References: Synthesis: Weijlard et al., J. Am. Chem. Soc. 78, 2342 (1956); US 2966490 (1960 to Merck & Co.).
Properties: Mp 83°.
 
Derivative Type: Dihydrochloride
CAS Registry Number: 126-12-5
Molecular Formula: C22H28N2O2.2HCl
Molecular Weight: 425.39
Percent Composition: C 62.12%, H 7.11%, N 6.59%, O 7.52%, Cl 16.67%
Properties: Crystals from methanol + ether, mp 280-287° (dec). Freely soluble in water, methanol. Solubility in ethanol: 8 mg/g. pH of aq solns 2.0 to 2.5. Solns are stable at pH 3.5 and below. At pH 4 and higher the insol free base is precipitated. uv max (pH 7 in 90% methanol contg phosphate buffer): 235, 289 nm (A1%1cm 293, 34.5). Distribution coefficient (water, pH 3.6/n-butanol): 0.9.
Melting point: mp 280-287° (dec)
Absorption maximum: uv max (pH 7 in 90% methanol contg phosphate buffer): 235, 289 nm (A1%1cm 293, 34.5)
 
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic).

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