Aprobarbital
Title: Aprobarbital
CAS Registry Number: 77-02-1
CAS Name: 5-(1-Methylethyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5-allyl-5-isopropylbarbituric acid; allypropymal
Trademarks: Alurate (Roche)
Molecular Formula: C10H14N2O3
Molecular Weight: 210.23
Percent Composition: C 57.13%, H 6.71%, N 13.33%, O 22.83%
Literature References: Prepn: US 1444802 (1923). Toxicity data: H. H. Frey, Arzneim.-Forsch. 12, 389 (1962).
Properties: Slightly bitter crystals, mp 140-141.5°. Almost insoluble in water, petr ether, aliphatic hydrocarbons. Sol in alcohol, chloroform, ether, acetone, benzene, glacial acetic acid, also in solns of fixed alkali hydroxides. A satd aq soln is acid to litmus. LD50 i.p. in mice: 200 mg/kg (Frey).
Melting point: mp 140-141.5°
Toxicity data: LD50 i.p. in mice: 200 mg/kg (Frey)
 
Derivative Type: Sodium salt
CAS Registry Number: 125-88-2
Additional Names: Aprobarbital sodium; sodium 5-allyl-5-isopropylbarbiturate
Molecular Formula: C10H13N2NaO3
Molecular Weight: 232.21
Percent Composition: C 51.72%, H 5.64%, N 12.06%, Na 9.90%, O 20.67%
Properties: Hygroscopic powder; slightly bitter taste. Very soluble in water; slightly sol in alc. Practically insol in ether. Aq solns are alkaline to litmus.
 
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.13.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Barbituric Acid Derivatives.

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