Bence-Jones Proteins
Title: Bence-Jones Proteins
Literature References: Low molecular weight, heat-sensitive proteins isolated from urine of multiple myeloma patients: Caputo, Aminoacidosi 7, 163-77 (1957), C.A. 54, 6841 (1960). Used as a model in structural studies of immunoglobulins, they are structurally homogeneous within each patient and antigenically related. Crystallographic structural study: E. E. Aeola et al., Biochemistry 19, 432 (1980). They constitute the light-chain component of myeloma globulin and have been implicated in the pathogenesis of amyloidosis, cf. G. G. Glenner, N. Engl. J. Med. 302, 1283 (1980); G. G. Glenner et al., Amyloid and Amyloidosis (Excerpta Medica, Amsterdam, 1980) p 351.
Properties: Coagulates on heating at 45-55°. Redissolves partially or wholly on boiling. Amino acid composition in g-%: Arginine 5.6, histidine 3.3, lysine 9.5, tyrosine 6.4, tryptophan 3.4, phenylalanine 4.2, cystine 2.6, methionine 1.9, serine 8.4, threonine 8.1, leucine 7.3, isolecine 2.2, valine 9.8, glycine 8.6, alanine 3.1, proline 6.9, glutamic acid 7.5, aspartic acid 9.2. The molecule also shows a carbohydrate content of 9.4% (mostly glucose, mannose, and glucosamine).

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