Benomyl
Title: Benomyl
CAS Registry Number: 17804-35-2
CAS Name: [1-[(Butylamino)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
Additional Names: 1-(butylcarbamoyl)-2-benzimidazolecarbamic acid methyl ester; methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate
Manufacturers' Codes: F-1991
Trademarks: Benlate (DuPont)
Molecular Formula: C14H18N4O3
Molecular Weight: 290.32
Percent Composition: C 57.92%, H 6.25%, N 19.30%, O 16.53%
Literature References: Prepn: H. L. Klopping, FR 1523597; eidem, US 3631176 (1968, 1971 both to du Pont). The degradation product, methyl 2-benzimidazolecarbamate, is thought to be the active component; see carbendazim. Antifungal activity and mode of action studies: Kilgore, White, Bull. Environ. Contam. Toxicol. 5, 67 (1970); Maxwell, Brody, Appl. Microbiol. 21, 944 (1971); Bartels-Schooley, MacNeill, Phytopathology 61, 816 (1971). Activity as catalyst in biological oxidation of sewage and fertilizers: Kouba, US 3649530 (1972 to du Pont). Toxicity: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972). Metabolism: J. A. Gardiner et al., J. Agric. Food Chem. 22, 419 (1974). Mutagenicity study: J. P. Seiler, Mutat. Res. 32, 151 (1975); H. Sherman et al., Toxicol. Appl. Pharmacol. 32, 305 (1975). Review: W. E. Bleidner et al., Anal. Methods Pestic. Plant Growth Regul. 10, 157-171 (1978).
Properties: White crystalline solid. Sol in chloroform. Insol in water or oil. LD50 orally in rats: >9590 mg/kg (Schafer).
Toxicity data: LD50 orally in rats: >9590 mg/kg (Schafer)
CAUTION: Potential symptoms of overexposure are irritation of eyes, skin and upper respiratory system; skin sensitization; possible reproductive and teratogenic effects. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 24.
Use: Fungicide; ascaricide.
Therap-Cat-Vet: Anthelmintic.

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